基于THE和QS评价指标的医学学科排名体系构建

目的：分析医学学科国际排名的影响因素，为我国医学学科发展提供参考。方法：在THE、QS排名指标的基础上，构建新的医学学科排名指标体系，运用统计学软件SPSS 24.0分析100所高水平医学大学的类型、特征，揭示不同类型大学的优势、劣势。结果：教育教学是各类型大学学科发展核心，亚洲大学国际化水平偏低，科研论文在THE和QS排名中作用有限，国内大学享有较好的国际声誉。结论：在我国医学学科建设中，应注重教学品质，重视高质量科研成果的产出，加快国际交流与合作、继续提升国际声誉。     

Successful retrieval of broken coiled guidewire from left atrium during balloon mitral valvotomy: A rare complication

Abstract

Balloon mitral valvotomy (BMV) is the procedure of choice for rheumatic mitral stenosis with favorable valve morphology. Fracture of 0.025 inch coiled guidewire during BMV is a very rare complication. The various factors which may cause this complication are utilization of reused hardware, improper placement of guidewire, abnormal angulation between guidewire and dilator with forceful septal dilation and rarely manufacturing defect. Here, we report successful retrieval of broken 0.025 inch coiled guidewire from left atrium during BMV using 10F Amplatzer long sheath without any complication.     

文献检索课一体化教学与开放实习室教学研究

研究文献检索课一体化教学与开放学习室的教学模式对教学效果的影响，对采用不同授课方法两组学生的考试成绩和各项能力进行分析统计，结果表明新的教学模式能明显提高学生考试成绩和各种能力并有助于提高教师水平。     

国际突发公共卫生事件研究主题演化分析

目的：探究国际突发公共卫生事件研究的主题演化。方法：以2021年以前Web of Science中有关突发公共卫生事件的2 509篇文献作为分析对象，使用SciMAT软件制作关键词重叠图、战略坐标图和主题演化路径图，对不同时间段国际突发公共卫生事件研究的核心主题和演化路径进行分析。结果：较为明显的主题演化路径有4条，分别是防护与治疗、灾害环境污染、应急响应系统和公众心理干预。结论：突发公共卫生事件领域的相关研究随着时间的推移，其内容不断丰富，主题类团演化能力不断增强，演化路径日趋平稳。早期的研究热点集中于防治与应对领域，随着时间的推移，研究热点逐渐由防治与应对转变为利用各类系统对突发公共卫生事件进行事前监测。利用信息系统进行事前监测的算法模型和与公众进行风险沟通将成为未来研究的热点。     

影响科技查新工作质量因素分析

本文对科技查新过程中科技查新点的提炼与归纳,查新检索用词及查新结论撰写几个方面进行探讨,分析影响查新工作质量因素的主要原因,分析其不足之处,并提出建议,力争在提高查新工作质量方面做出努力,确保查新工作质量的准确性。     

Pharmacy Student Self-Testing as a Predictor of Examination Performance

Objectives. To determine if student self-testing improves performance during a doctor of pharmacy course.Methods. Students were given access to online quizzes with a large pool of randomly selected questions specific to upcoming examination content. Quizzes were electronically scored immediately upon completion and students were provided corrective feedback.Results. Examination scores following implementation of the practice quizzes were significantly higher in all but the last testing period. The upper fiftieth percentile of students scored higher on both the practice quizzes and subsequent examinations in all but the fourth testing period.Conclusions. Providing pharmacy students with self-testing opportunities could increase their retention of course material and provide feedback to both students and educators regarding learning, as well as provide students with a measure of their metacognition.     

Pneumococcal conjugate vaccine against serotype 3 pneumococcal pneumonia in adults: A systematic review and pooled analysis

BackgroundSerotype 3 pneumococcal disease has not substantially declined at the population level after the routine introduction of 13-valent pneumococcal conjugate vaccine (PCV13) into pediatric immunization programs across the globe. This epidemiological finding has generated debate regarding the effectiveness of PCV13 against serotype 3 disease. Evaluating PCV13 effectiveness against serotype 3 is especially critical in adults, where serotype 3 makes up an important amount of remaining pneumococcal disease.MethodsWe performed a systematic review of the published literature to assess the direct effectiveness of PCV13 against serotype 3 community-acquired pneumonia (CAP) among adults. We then estimated overall vaccine effectiveness (VE) using a pooled analysis of the individual-level, raw data.ResultsTwo published studies met inclusion criteria. One was a randomized controlled trial conducted in the Netherlands and published in 2014. The other was a recently-published case-control study conducted in Louisville, Kentucky that used a test-negative design (TND). We also identified a third TND study conducted in Argentina that was recently presented as a conference abstract but is not yet published. All three studies were conducted in adults aged ≥65 years. PCV13 VE against serotype 3 hospitalized CAP was 52.5% (95%CI: 6.2–75.9%) from the pooled analysis of individual-level data from all three studies. Results were similar if the unpublished estimate was excluded (serotype 3 VE = 53.6% [95%CI: 6.7–76.9%]). No heterogeneity was observed.ConclusionsCurrently-available evidence, although limited to three studies, suggests that PCV13 provides direct protection against serotype 3 hospitalized CAP in adults aged ≥65 years.     

Effects of the loss and reconstruction of molar occlusal support on memory retrieval and hippocampal neuron density in rats

PurposeAnimal experiments have shown that the loss of occlusal support causes impairments in spatial cognition. Many reports have focused on the memory encoding process, and only few studies have investigated the effect on memory retrieval. This study aimed to examine the effects of both the loss and reconstruction of occlusal support on the memory retrieval process and on the number of hippocampal pyramidal cells.MethodsThe experimental animals were divided into a molarless group, in which molars were extracted, a denture-wearing molarless group with experimental dentures inserted after molar extraction, and a control group. Radial maze trials were performed for 20 consecutive days (acquisition phase). The rats were tested on long-term memory retention following the acquisition phase in eight trials every five days, and in an additional trial 20 days later (probe phase).ResultsThe denture-wearing molarless group showed higher levels of spatial learning and memory than the molarless group. There were no significant differences in memory retrieval during the probe phase between the denture-wearing molarless and the control group. The molarless group showed significantly worse spatial learning and memory and had fewer neurons in the hippocampus than the control group.ConclusionsOur results suggest that the loss of occlusal support decreases the number of pyramidal cells in the hippocampus and impairs memory decoding and retrieval. However, this effect is suppressed by the reconstruction of occlusal support.